Humoral Control of the Erythropoiesis During Altitude Changes

摘要

Some aspects of the inhibitory effect of plasma obtained from altitude natives who sojourned to sea level for 9 to 11 days were studied, as well as the effect of plasma from polycythemic dogs exposed to hyperbaric pressure of 4 atmospheres, and rats previously stimulated in low pressure chamber. Total plasma from altitude natives after 9 days at sea level produced less incorporation of Fe-59, than did normal plasma from sea level subjects. There is good relationship between administered dose and depressing effect. The depressing effect of plasma from altitude natives, brought down to sea level, on young nucleated red cells is evident. Plasma from polycythemic dogs exposed to hyperbaric pressure of 4 atmospheres produced less incorporation of Fe-59 on stimulated rats, in comparison with rats having plasma from normal sea level dogs or saline. (Author)