Catecholamine, Corticosteroid and Ketone Excretion in Exercise and Hypoxia.

摘要

Four subjects undertook light exercise each working day for two consecutive weeks, during one of which the experiment was carried out under hypoxic conditions. The excretions of adrenaline, noradrenaline and 17-hydroxycorticosteroids (17-OHCS) were measured during the stress and also overnight, and urines were tested for the presence of ketone bodies. The excretion of adrenaline and 17-OHCS in stress was highest on the first day of each week. In general, the excretion of adrenaline was higher throughout the first, as compared with the second, week. These results are considered to be indicative of adaptation to stress. Only noradrenaline showed significantly higher excretion in hypoxia. Throughout the experiment excretion of 17-OHCS during the stress period was below normal levels, suggesting 'retention' of steroids in stress rather than increased adrenocortical activity. However, 17-OHCS excretion tended to be higher during the experimental period and subsequently lower overnight during the hypoxia week. Ketosis occurred in two subjects. In one of these it could be readily related to previous extraneous stress. Excretion of unidentified ketones in overnight urines was sometimes suspected and occurred beyond doubt following gross ketosis. (Author)