Lung Metabolism, Function, and Morphology during Hyperoxic and Hyperbaric Exposure.

摘要

Productivity resulting from the multi-disciplinary approach we have been developing for studying 02 toxicity is obvious. We have quite thoroughly defined (both qualitatively and quantitatively) the temporal sequalae of cardiopulmonary structural changes associated with onset, duration, and intensity of 02 exposure as well as changes due to varying the rate of withdrawal from the hyperoxic environment. Theses studies in rats, rabbits, and hamsters have been extended to testing a variety of pharamacologic as well as dietary manipulations which alter tolerance to pilmonary 02 toxicity and hypoxic pulmonary vasoconstriction. At present, each bit of information obtained continues to direct us toward microsonal enzymes and serotenergie regulation. Our major goals for Year 05 involve studies directed at the involvement of these systems in the oxygen-related insults.