Lung Metabolism, Function, and Morphology during Hyperoxic and Hyperbaric Exposure.

摘要

Indolamine 2,3 dioxygenase has been found in human lung; this enzyme has potential as an important oxygen radical scavenger, MK421, is a non-sulfhydryl group angiotensin-converting-enzyme inhibitor which was found not to alter adrenergic responsiveness, Neuron-specific-enolase and 5-HT immunoreactive lung neuroendocrine cell populations are not the same in the fetal monkey lung implying that either development rates are not the same or more than one population is present, a possible genetic relationship between cytochrome P-450 enzyme induction and oxidative stress has been established implying that the susceptibility to oxygen toxicity may be inherited as well as environmental, Selenium and vitamin E deficiency may cause a decrease of the medial thickness in small pulmonary arteries implying that regulation of smooth muscle reactivity may be related to levels of organic hydroperoxides, lipid peroxidation, lipoxygenase or cyclooxygenase products, or a change in platelet activation status, The smallest subunit of Lipid A,Lipid X (mol.wgt. 711) has been characterized and causes all of the physiological effects on the pulmonary circulation seen with complete endotoxin, and finally Venous dispersion of lung 5-HT uptake kinetics using the bolus injection technique were different when trace doses were superimposed on constant background concentrations.