Effects of Nonadecafluorodecanoic Acid on Tissue Fatty Acids of the Rat.

摘要

The effects of intraperitoneal injection of nonadecafluoro-n-decanoic acid (NDFDA) on liver, testes, and blood fatty acids were investigated. The hypothesis that NDFDA affects the relative amounts of the six major tissue fatty acids was tested. Effects of fatty acid ratios observed after NDFDA exposure were compared with those seen after injection of propylene glycol, injection of propylene glycol with pair-feeding, and injection and perfluorooctanoic acid (PFOA). The lethal response of rats injected with NDFDA, when plotted on a log dose versus time basis, does not appear similar to that of rats injected with PFOA. At higher doses, there is a similarity in response, but, as the dosage is lowered, a second mechanism of toxicity seems to occur in NDFDA-treated rats. Compared with control ratios, the greatest changes in relative amounts of the six major fatty acids after treatment with NDFDA occur in the liver. The mechanisms of toxicity of NDFDA remain in doubt. Oxidation of fatty acids leading to production of prostaglandins or other biologically-active derivatives which adversely affect physiological activities may be occurring. The decrease in relative fraction of arachidonic acid may give credence to this theory. A direct effect on membrane function can also be advocated since recent experimentation has demonstrated a decreased erythrocyte osmotic fragility in rats injected with NDFDA.