Correlation between Plasma Fibronectin Level and Mortality Following Experimental Rate Heat Stress

摘要

Reticuloendothelial system (RES) clearance function correlates with the mortality rate associated with stresses which can induce shock. Likewise, mortality rate after experimental rat heat stress (ERHS) is altered by modulation of RES function. Since plasma fibronectin (PF) mediates in vivo phagocytosis by the RES, the relationship between mean plasma fibronectin level (MPFL) and mortality after ERHS was examined. A comparison of MPFLs prior to ERHS revealed that rats which ultimately comprised the survival group had a MPFL (269.0 + 11.2 microgram/ml) which exceeded the value determined for the non-survivors (252.9 + or - 11.9 microgram/ml). Both groups had elevated MPFLs, up to 12 h following ERHS. However, after this time, MPFL began to decline. The decline was more severe for the non-survivors, with MPFLs at 15, 18, and 24 h, significantly (p<0.01) lower than the values for the survival group.