Effect of Prostacyclin, Indomethacin, and Heparin on Postischemic Nerve Cell Function

摘要

Therapeutic administration of PGI2 and indomethacin beginning 5 min after ischemia in heparizinized animals eliminated the zones of greatly reduced flow. Thus, PG12 and indomethacin seemed capable to counteracting the process leading to impairment of microvascular perfusion when given therapeutically to heparinized animals. In these studies, blood flow was the primary variable of concern, and no index of neuronal function was measured, so that conclusions could not be drawn regarding the potential capacity of this drug combination to promote neuronal recovery after ischemia. Therefore we developed a model of reversible focal ischemia in which the cortical sensory evoked response served as a quantifiable index of neuronal function. The influence of heparin, PGI2, and indomethacin on postischemic nerve cell recovery was then investigated in this model. In addition, we studied the relationship between focal blood flow and platelet accumulation in the same model.