Determination of the Phase Ratio by Means of Reaction Kinetics in a Liquid Chromatographic Reactor

摘要

The on-column rate constants in an octadecylsilane (ODS) bonded liquid chromatographic reactor with methanol mobile phase were used to determine the phase ration and catalyst distribution coefficient. A concentration factor and the extent of ODS participation were introduced to treat the contribution of the non-polar alkyl ligands to solute retention in the composite stationary phase. The results obtained from this operational approach which can be expanded to other systems are quite comparable to literature values, and the discrepancies are discussed.