Behavioral Effects of Non-Opioid Antitussive Anticonvulsants. (Reannouncement with New Availability Information).

摘要

Many of the currently used anticonvulsants possess a host of undesirable pharmacological properties. Several non-opioid antitussives bind to high-affinity (H)dextromethorphan sites in the brain and have novel anticonvulsant activity. Because these compounds may lack side effects possessed by currently used anticonvulsants, they may be useful in the treatment of some epilepsies, either alone or as adjuncts. Behavioral effects of these as well as clinically used anticonvulsant drugs were studied under a standard preclinical test of sedative-hypnotic/anxiolytic activity which generally yields positive results with standard anticonvulsants. Lever-press responses of male Sprague-Dawley rats were maintained under a multiple schedule of food presentation in which responses in one component were suppressed by brief electric shock (punishment) whereas responses in an alternate component were not punished.