Influence of Ionic Composition of the Medium on Acetylcholinesterase Conformation

摘要

The recent crystallographic analysis of a dimeric glycophospholipid form of AchEfrom Torpedo californica (Sussman et al., 1991) provides an ideal opportunity for comparing the catalytic behaviour and recognition properties of the enzyme. with its atomic structure. The globular subunit is determined to be an alpha/Beta protein containing numerous crossover motifs of the type Beta-alpha-Beta or Beta-loop-Beta. The catalytic residue, Ser200, resides 4 A above the base of a 20 A