Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds(Evaluation of Two Unicharged Propellants in the Primary Dermale irritation Study)

摘要

Bis (2,2-dinitropropyl) acetal/formal (-50/50 mixture) +/diphenyl aminestabilizer (BDNPA/F+/-DPA) were tested for dermal irritation. one group of six rabbits per study were dermally exposed to the test article for four hours. Animals were observed for erythema and edema at 30-60 minutes, 24, 48 and 72 hours after dosing. Based upon the results of these assays, BDNPA/F+DPA and BDNPA/F-DPA were determined to be non-irritants. (Primary Dermal Irritation Index for both test articles=O.O) The Dermal Irritation Toxicity Category for both test articles is Class Iv. Dermal irritation, Unicharge, Propellants, Bis-(2,2dinitropropyl)acetal, Bis-(2,2-dinitropropyl) formal, Lab animals, RAIII.