Contribution of Tissue Lipid to Long Xenon Residence Times in Muscle

摘要

Experiments demonstrate that the mean residence time of an inert gas in tissue islonger than that predicted by a single-compartment model of gas exchange. Also the relative dispersion (RD), the standard deviation of residence times divided by the mean) is 1 according to this model, but RDs in real tissues are closer to 2, suggesting that a multiple-compartment model might be more accurate. The residence time of gas is proportional to its solubility in the tissue. Although the noble gases in particular are 10 times more soluble in lipid than in nonlipid tissues, models of gas exchange generally do not incorporate measurements of the lipid in tissue, which may lead to error in the predicted gas residence times. Could a multiple compartment model that account for the lipid in tissue more accurately predict the mean and RD of gas residence time.