Mismatch Negativity (MMN) Indexes Subclinical Neurological Differences in HIVPatients during Rapid Perceptual Processing

摘要

Thirteen asymptomatic HIV-infected (HIV+) and 13 healthy control (HIV-) subjectswere instructed to detect 'oddball'; target tones from among a sequence of nontarget tones delivered rapidly (3 tones/sec) in one ear while ignoring a similar sequence delivered simultaneously in the opposite ear. Event-related potentials (ERPs) to all stimuli were recorded from midline scalp sites. Both groups produced ERP correlates, termed the mismatch negativity (MMN), to the oddball tones during delivery. However, the HIV+ group produced MMNs that were