Amino Acid Sequences of a Heterodimeric Neurotoxin from the Venom of the FalseHorned Viper (Pseudocerastes Fieldi)

摘要

B. Francis, A. Bdolah and I. I. Kaiser. Amino acid sequences of a heterodimericneurotoxin from the venom of the false horned viper (Pseudocerastes fieldi). Toxicon 33, 863-874, 1995. The main toxic component of the venom of the false horned viper, Pseudocerastes fieldi, is a heterodimeric neurotoxin composed of a basic subunit, Cb II, and one of two acidic subunits, either Cb I(alpha) or Cb I(Beta). The nontoxic acidic subunit increases the toxicity of the basic subunit. Both subunits have phospholipase A2 (PLA2) amino acid sequences. Cb I(alpha) and Cb I(Beta) themselves are inactive towards phosphatidylcholine and when complexed with Cb II promote a delay in the onset of phospholipase activity of Cb II. Cb