Endovascular laser-tissue interactions redefined: shining light on novel windows of therapeutic opportunity beyond selective photothermolysis.

摘要

The most widely used treatment of port wine stains (PWSs) entails the flashlamp-pumped pulsed dye laser, which was developed in conformity with the theory of selective photothermolysis. This noninvasive treatment modality relies on the conversion of radiant energy to heat by hemoglobin and the ensuing coagulation of blood and necrosis of (peri-) vascular tissue due to thermal diffusion. By irradiating skin at a well-absorbed wavelength and sufficient irradiance, supracritical temperatures (>70degC) can be generated in the vessel lumen and confined spatially if the pulse duration is kept within the thermal relaxation time of blood and target vasculature, resulting in photocoagulation of the vascular lumen.