Synthesis and Fungitoxicity of C-phenyl Substituted Benzal-4- fluoroanilines

摘要

Eight C-phenyl substituted benzal-4-fluoroanilines(I-VIII)were synthesized by condensing 4-fluoroaniline with benzaldehyde and substituted benzaldehydes in equimolar ratio.The structures of compounds I-VIII were established on the basis of elemental analysis and spectral studies.The band at 260-280 nm in UV and approx 1625 cm~(-1)in IR indicated the presence of carbon-nitrogen double bond.In PMR spectra the one proton singlet at delta 8.3 was assigned to azomethinic proton.In mass spectra the molecular ion peak constituted the base peak.The compounds I-VIII were screened in vitro for their antifungal activity against Alternaria alternata,Fusarium oxysporum,Myrothecium roridum,Colletotrichum capsici and Ustilago tritici.Some of the compounds have shown moderate activity against A.alternata,C.capsici and M.roridum.