A NEW FACILE, HIGH YIELDING AND EFFICIENT PROTOCOL FOR THE SYNTHESIS OF NOVEL 4-PHENYLSULFONAMIDO-6-ARYL-2-PHENYLPYRIMIDINE-5-CARBONITRILE DERIVATIVES

摘要

A series of novel 4-phenylsulfonamido-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives have been synthesized through a two-step process. This protocol includes a facile surfactant-mediated methodology for the synthesis of 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives through a one-pot, three-component reaction in the presence of a catalytic amount of cetyltrimethylammonium bromide in water. No additional organic solvents and oxidants were used. The pyrimidine-5-carbonitrile products were then subjected to a direct sulfonylation of 4-amino group to 4-phenylsulfonamide-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives in the presence of sodium hydride in tetrahydrofuran solution. These new structures were confirmed by H-1- and (CNMR)-C-13 spectroscopy as well as mass spectrometry and elemental analyses.