A convenient synthesis of 2-amino-1,3-selenazoles using ionic liquids and microwave irradiation

摘要

A simple and environmentally benign synthesis of 2-amino-1,3-selenazoles by microwave irradiation using 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF_4) ionic liquid (IL) is described. Acyl halides, phenacyl halides, and-bromo-keto esters easily undergo condensation with selenourea in ([Bmim]BF_4) by microwave irradiation to afford the desired products of good purity in excellent yields. The ionic liquid can be easily recovered and reused at least 10 times without losing its activity. The duration of the reaction ranges from 4-6 min. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.