Structural and functional architecture of respiratory networks in the mammalian brainstem

摘要

Neural circuits controlling breathing in mammals are organized within serially arrayed and function_ally interacting brainstem compartments extending from the pons to the lower medulla. The core circuit components that constitute the neural machinery for generating respiratory rhythm and shaping inspiratory and expiratory motor patterns are distributed among three adjacent structural compartments in the ventrolateral medulla: the B_tzinger complex (B_tC), pre-B_tzinger complex (pre-B_tC) and rostral ventral respiratory group (rVRG). The respiratory rhythm and inspiratory_expiratory patterns emerge from dynamic interactions between: (i) excitatory neuron populations in the pre-B_tC and rVRG active during inspiration that form inspiratory motor output; (ii) inhibitory neuron populations in the pre-B_tC that provide inspiratory inhibition within the network; and (iii) inhibitory populations in the B_tC active during expiration that generate expiratory inhibition. Network interactions within these compartments along with intrinsic rhythmogenic properties of pre-B_tC neurons form a hierarchy of multiple oscillatory mechanisms. The functional expression of these mechanisms is controlled by multiple drives from more rostral brainstem components, including the retrotrapezoid nucleus and pons, which regulate the dynamic behaviour of the core circuitry. The emerging view is that the brainstem respiratory network has rhythmogenic capabilities at multiple hierarchical levels, which allows flexible, state-dependent expression of different rhyth_mogenic mechanisms under different physiological and metabolic conditions and enables a wide repertoire of respiratory behaviours.