Determination of the purity of valine by isocratic liquid chromatography coupled with charged aerosol detection (CAD)

摘要

A liquid chromatography coupled with charged aerosol detection (LC-CAD) procedure; capable of separating and quantifying the most common impurities of valine at levels as low as 0.05 % (m/m), has been developed.The procedure is simple (isocratic), rapid, linear, sensitive and repeatable. It employs a widely available and inexpensive stationary phase (C18).