In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano (TM) Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs

Tahara Kohei; Nishikawa Masahiro; Matsui Ko; Hisazumi Koji; Onodera Risako; Tozuka Yuichi; Takeuchi Hirofumi

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In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano (TM) Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs

机译：使用PureNano（TM）连续结晶器制备的药物纳米颗粒的体外和体内表征，可改善水溶性差的药物的生物利用度

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摘要

The aim of this study was to enhance the dissolution and oral absorption of poorly water-soluble active pharmaceutical ingredients (APIs) using nanoparticle suspensions prepared with a PureNano (TM) continuous crystallizer (PCC).

机译：这项研究的目的是使用由PureNano（TM）连续结晶器（PCC）制备的纳米颗粒悬浮液来增强水溶性差的活性药物成分（API）的溶解和口服吸收。

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《Pharmaceutical research》 |2016年第9期|共10页
作者
Tahara Kohei; Nishikawa Masahiro; Matsui Ko; Hisazumi Koji; Onodera Risako; Tozuka Yuichi; Takeuchi Hirofumi;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
crystallization; nanoparticles; PureNano;

机译：结晶;纳米颗粒;纯纳米;

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1. In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano (TM) Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs [J] . Tahara Kohei, Nishikawa Masahiro, Matsui Ko, Pharmaceutical research . 2016,第9期

机译：使用PureNano（TM）连续结晶器制备的药物纳米颗粒的体外和体内表征，可改善水溶性差的药物的生物利用度
2. Improved oral bioavailability of anticancer drug tamoxifen through complexation with water soluble cyclodextrins: in vitro and in vivo evaluation [J] . Erdogar Nazli, Nemutlu Emirhan, Iskit Alper B., Journal of Inclusion Phenomena and Macrocyclic Chemistry . 2020,第1a2期

机译：通过络合与水溶性环糊精的络合改善抗癌药物的口服生物利用度：体外和体内评价
3. Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin [J] . Jie Lai, Jianming Chen, Yi Lu, AAPS PharmSciTech . 2009,第3期

机译：甘油单油酸酯/泊洛沙姆407立方纳米颗粒作为口服药物输送系统：I.水溶性较差的药物辛伐他汀的体外评估和口服生物利用度的提高
4. Influence of Particle Size on Bioavailability and Rate of Absorption For Oral Dosage Forms Prepared From Poorly Water Soluble Drugs: A Comparison Between in-silico, in-vitro and invivo Pharmacokinetic Data. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：粒度对水溶性药物不良制备的口服剂型生物利用度的影响及其吸收率：硅，体外和Invivo药代动力学数据的比较。
5. Improved Bioavailability and Site Specific Delivery of Poorly Water Soluble Drugs through the Production of Stabilized Drug Nanoparticles. [D] . Vaughn, Jason Michael. 2010

机译：通过生产稳定的药物纳米颗粒，改善了水溶性差的药物的生物利用度和定点递送。
6. Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin [O] . Jie Lai, Jianming Chen, Yi Lu, 2009

机译：甘油单油酸酯/泊洛沙姆407立方纳米颗粒作为口服药物输送系统：I.水溶性较差的药物辛伐他汀的体外评估和口服生物利用度的提高
7. Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin [O] . Lai, Jie, Chen, Jianming, Lu, Yi, 2009

机译：甘油单油酸酯/泊洛沙姆407立方纳米颗粒作为口服药物输送系统：I.水溶性较差的药物辛伐他汀的体外评估和口服生物利用度的提高

In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano (TM) Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs

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