Synthetic Peptide Analogs of Somatostatin: Trends in the Synthesis of and Prospects in the Search for New Anticancer Drugs

摘要

The native hormone somatostatin plays an important role in vivo by acting on multiple targets via a family of five receptors to produce a broad spectrum of biological effects. Some peptide analogs of this enzyme are widely used in clinical practice. However, their clinical efficacy is limited because of some disadvantages. In this respect, the search for new drugs of this type is a critical task. In this review, we have summarized trends in the synthesis and biological effects of peptide somatostatin analogs since 1978 and future prospects for the development of these anticancer drugs.