Locked-in syndrome in three children with Guillain-Barré syndrome

摘要

We read with interest the case report by Dr. Medici et al. [1], in which locked-in syndrome owing to Guillain-Barre Syndrome was diagnosed in three patients. However, we should raise some concerns about the diagnosis of locked-in syndrome in Guillain-Barre syndrome. Here we refer to the first case as an example to argue against their diagnosis.Locked-in syndrome is a rare consequence of brain damage caused by a brainstem lesion in the central nervous system, but Guillain-Barre syndrome is an immune-mediated inflammatory disease of the peripheral nervous system. The authors failed to confirm that Guillain-Barre syndrome involved the brainstem in this patient.