Recent News in the Glioblastoma Research

摘要

Glioblastoma multiforme (GBL) is the most frequent and aggressive tumor of the brain. Mean survival time of GBL patients is only 12-15 months, despite most intensive treatments. To fight this severe, still almost incurable disease, a great number of researches are recruited. Here we review the results of the GBL investigations published recently (from the end of 2013 to the first half of 2014) that ensured a considerable progress in this field of oncology. Combination of DNA and RNA sequencing and functional validation made it possible to define a somatic genomic landscape of GBL, to uncover new genetic driver alterations in GBL, and to suggest new approaches for the treatment of GBL. The results of the GBL immunotherapy are discussed.