Synthesis of Fueetlonallzed Pyrrolidines by a Highly Stereoselective [3+2]-Annillation Reaction of iV-Tosyl-a-Amino Aldehydes and 1,3-Bis(silyl)propenes

摘要

An efficient protocol for stereoseleclive construction of densely functionalized pyrrolidines by a [3+2]-annulation reaction of N-tosyl-α-anuno aldehydes and l,3-bis(sily])propenes is described. This methodology is also applied as a key step in the synthesis of the polyhydroxylated pyrrolidine alkaloid 2,5-dideoxy-2,5-imino-n-glucitol (DGDP).