Simple and improved procedure for the regioselective acylation of aromatic ethers with carboxylic acids on the surface of graphite in the presence of methanesulfonic acid

摘要

Friedel-Crafts acylation of aromatic compounds such as anisole has been successfully carried out using the combination of graphite with MeSO3H. Both aromatic and aliphatic carboxylic acids reacted smoothly under the conditions to afford the corresponding aromatic ketones in high yield.