Formation of five- and six-membered heterocyclic rings under radical cyclization conditions

摘要

This review describes the formation of five- and six-membered heterocyces in various organic molecules by radical cyclization and covers the progress made on the topic during the period of 2008 through 2010. 1 Introduction 2 Reagents, Solvents, Radical Initiators, and Reactivity 3 General Mechanistic Pathways: Regio- and Stereoselectivity 4 Synthesis of Nitrogen Heterocycles 4.1 Nitrogen-Centered Radical Cyclizations 4.2 N-Vinylic and Related Systems 4.3 N-Allylic and Related Systems 4.4 N-Alkyl and Related Systems 4.5 Diastereoselective Radical Cyclizations 4.6 Cascade and Tandem Radical Cyclizations 4.7 Atom- and Group-Transfer Radical Cyclizations 4.8 Oxidative Radical Cyclizations 4.9 Miscellaneous 5 Synthesis of Oxygen Heterocycles 5.1 Diastereoselective Radical Cyclizations 5.2 Miscellaneous 6 Synthesis of Sulfur Heterocycles 7 Synthesis of Silicon Heterocycles 8 Miscellaneous 9 Conclusions.