Polymer-Based of Extract-Loaded Nanocapsules Aloe vera L. Delivery

摘要

Aloe vera L. is the oldest medicinal plant ever known and the most applied medicinal plant worldwide. Preparations of nanocapsule made from the plant A. vera used in cosmetic and alternative medicine industries regularly make claims regarding the soothing, moisturizing, and healing properties of A. vera. The aim of this work is to formulate or to prepare rather than to extract stable nanocapsules with core-shell structure by method of emulsion and penetration to solvent. In this method of producing nanocapsules, the organic phase containing a certain amount of copolymer, A. vera extract, and olive oil was prepared in an acetone solvent, and the organic solution was then added drop by drop to the spinning water at a moderate pace at room temperature. The obtained suspension was immediately dissolved under sonication and then the acetone was removed under vacuum environment. Finally, the solutions were transferred into a freeze dryer and the final product was a white powder nanocapsule containing the extract. The influence of some factors such as the ratio of polymer to oil and concentration of polymers and plant extract determine the size of the nanocapsule. The nanocapsules were identified by scanning electron microscopy (SEM) and particle size analysis report (PSAR), Fourier-transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance (NMR).