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首页> 外文期刊>Parkinsonism & related disorders >Dopamine replacement therapy does not restore the ability of Parkinsonian patients to make rapid adjustments in motor strategies according to changing sensorimotor contexts.
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Dopamine replacement therapy does not restore the ability of Parkinsonian patients to make rapid adjustments in motor strategies according to changing sensorimotor contexts.

机译:多巴胺替代疗法不能恢复帕金森病患者根据不断变化的感觉运动环境快速调整运动策略的能力。

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摘要

The ability of dopamine replacement to restore rapid motor adjustments in Parkinson's disease (PD) was investigated. Medicated and non-medicated patients performed finger-to-nose movements while simultaneously bending the trunk forward, without vision. Trunk motion was blocked unexpectedly, necessitating rapid adjustments in arm trajectories. Patients exhibited irregular hand paths, plateaus in hand velocity, and prolonged movement times, which were significantly greater in perturbed trials. Medication improved kinematics but perturbation-induced disturbances persisted and did not approximate the levels of non-perturbed trials nor those of controls. Dopaminergic replenishment in PD may therefore have limited restorative benefits for rapid context-specific motor control.
机译:研究了多巴胺替代物恢复帕金森氏病(PD)的快速运动调节的能力。药物治疗和非药物治疗患者均进行了从鼻子到鼻子的动作,同时使躯干向前弯曲,没有视力。躯干运动意外被阻止,因此需要快速调整手臂的运动轨迹。患者表现出不规则的手部路径,手部速度的平稳期和延长的运动时间,这在受扰的试验中明显更大。药物治疗改善了运动学,但扰动引起的干扰持续存在,且未接近无扰动试验或对照组的水平。因此,PD中多巴胺能补给对于快速的特定于上下文的运动控制可能具有有限的修复益处。

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