Impairment of motor cortex plasticity in Parkinson's disease, as revealed by theta-burst-transcranial magnetic stimulation and transcranial random noise stimulation.

摘要

Pathophysiological studies in Parkinson's disease (PD) have highlighted pathological hypoactivity in the supplementary motor area (SMA), the dorsolateral prefrontal cortex (DLPFC) and the primary motor cortex (Ml) [1]. Transcranial stimulation techniques like intermittent Theta-burst stimulation (iTBS) [2] and transcranial random noise stimulation (tRNS) [3] offer the possibility of increasing regional motor-cortical excitability in healthy persons for up to 60 min after stimulation. This study evaluated stimulation-induced cortical plasticity of iTBS and tRNS in patients with PD.