Elevated salivary protein in Parkinson's disease and salivary DJ-1 as a potential marker of disease severity

摘要

Introduction: There is an urgent need to identify robust biomarkers for Parkinson's disease (PD). Previous studies have shown changes in composition and secretion of saliva in patients with PD, including an increase in salivary DJ-1 concentration. Autonomic dysfunction is a known feature of PD and could contribute to abnormal salivary gland function.