Catalytic asymmetric cyanoethoxycarbonylation of aldehydes using self-assembled titanium catalysts

摘要

A new self-assembled titanium catalyst system has been developed for the asymmetric cyanoethoxycarbonylation of aldehydes which produced the desired products in moderate to excellent yields (up to 99%) with high enantioselectivities (up to 94% ee) under mild conditions. The catalyst was readily prepared from tetraisopropyl titanate [Ti(Oi-Pr)(4)], a Schiff base, and cinchonine.