A Sialyl-Lewis A-asparagine building block for glycopeptide-synthesis

摘要

Using the azido group as the anomeric protection a Sialyl Lewis A tetrasaccharide was synthesized from N-acetylglucosamine via the type 1 lactosamine and Lewis A intermediates. After reduction of the azido group, coupling with Fmoc alpha-allyl aspartate and Pd(0)-catalyzed deallylation, the Sialyl Lewis A asparagine building block was obtained. [References: 30]