Efficient synthesis of optically active 2-azido-1-arylethanols via oxazaborolidine - Catalysed asymmetric borane reduction

摘要

A simple, efficient, stereo- and regio-selective method for the synthesis of optically active 2-azido-1-phenylethanols by asymmetric reduction of 2-azidoacetophenones with in situ generated, oxazaborolidine-borane complexes in THF, is described. This new method appears to be an alternative to the classical methods previously reported. [References: 24]