aza-annulation of tetrahydroisoquinoline derived enamines: Efficient and convergent routes to novel functionalized benzo[a]quinolizin-4-ones and pyrimido[6,1-a]isoquinoline derivatives

摘要

The 1,2,3,4-tetrahydroisoquinoline derived push-pull enaminones and nitroenamine have been investigated in aza-annulation reactions with various 1,3-biselectrophiles leading to the synthesis of novel functionalized benzo[a]quinolizin-4-ones and pyrimido[6,1-a]isoquinoline derivatives. [References: 34]