Expression of estrogen-induced genes and estrogen receptor β in pancreatic neuroendocrine tumors: implications for targeted therapy.

Jeannelyn S Estrella; Ly T Ma; Denái R Milton; James C Yao; Huamin Wang; Asif Rashid; Russell R Broaddus

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Expression of estrogen-induced genes and estrogen receptor β in pancreatic neuroendocrine tumors: implications for targeted therapy.

机译：胰腺神经内分泌肿瘤中雌激素诱导基因和雌激素受体β的表达：对靶向治疗的意义。

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Our study showed that PanNETs with favorable prognostic features have higher ERβ expression, which is associated with up-regulated PR and EIG121 messenger RNA expression. Estrogen regulation in PanNETs could potentially help in risk stratification and provide a rational target for novel treatment strategies.

机译：我们的研究表明，具有良好预后特征的PanNETs具有较高的ERβ表达，这与PR和EIG121信使RNA表达上调有关。 PanNETs中的雌激素调节可能有助于风险分层，并为新的治疗策略提供合理的目标。

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《Pancreas》 |2014年第7期|共7页
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Jeannelyn S Estrella; Ly T Ma; Denái R Milton; James C Yao; Huamin Wang; Asif Rashid; Russell R Broaddus;
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正文语种 eng
中图分类消化系及腹部疾病;
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1. Expression of estrogen-induced genes and estrogen receptor β in pancreatic neuroendocrine tumors: implications for targeted therapy. [J] . Jeannelyn S Estrella, Ly T Ma, Denái R Milton, Pancreas . 2014,第7期

机译：胰腺神经内分泌肿瘤中雌激素诱导基因和雌激素受体β的表达：对靶向治疗的意义。
2. Differential regulation of c-fos expression in estrogen-induced hamster renal tumors compared with kidney not due to creation of an estrogen-response element by point mutation in the gene's flanking sequence. [J] . Sarabia SF, Liehr JG Molecular Carcinogenesis . 1999,第4期

机译：与雌激素引起的仓鼠肾肿瘤相比，c-fos表达的差异性调节不同于肾脏，这并不是由于基因侧翼序列中的点突变产生了雌激素反应元件。
3. Intratumoral Estrogen Concentration and Expression of Estrogen-Induced Genes in Male Breast Carcinoma: Comparison with Female Breast Carcinoma [J] . TakagiK., MoriyaT., KurosumiM., Hormones & cancer . 2013,第1期

机译：男性乳腺癌中的肿瘤内雌激素浓度和雌激素诱导基因的表达：与女性乳腺癌的比较
4. ~(213)Bi-DOTATOC receptor targeted alpha-radionuclide therapy induces remission in neuroendocrine tumors refractory to beta-radiation - a first in human study [C] . Giesel FL, Kratochwil C, Bruchertseifer F, 8th International Conference on Isotopes 2014 . 2014

机译：〜（213）Bi-DOTATOC受体靶向的α-放射性核素疗法可诱导难于β辐射的神经内分泌肿瘤缓解-这是人类研究中的首次
5. Ligand- and phosphorylation-dependent modulation of estrogen receptor target gene expression. [D] . Koterba, Kristen L. 2006

机译：雌激素受体靶基因表达的配体和磷酸化依赖性调节。
6. Expression of Estrogen-Induced Genes and Estrogen Receptor Beta in Pancreatic Neuroendocrine Tumors: Implications for Targeted Therapy [O] . Jeannelyn S. Estrella, Ly T. Ma, Denái R. Milton, -1

机译：胰腺神经内分泌肿瘤中雌激素诱导基因和雌激素受体β的表达：靶向治疗的意义。
7. Over expression of vascular endothelial growth factor and its receptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tumor angiogenesis [O] . S. Banerjee 1997

机译：在雌激素诱导的大鼠垂体肿瘤发育过程中，在血管内皮生长因子及其受体的表达可能介导雌激素引发的肿瘤血管生成
8. Role of Skp1-Cul1-F-Box Ubiquitin Ligases in Src-Stimulated Estrogen Receptor Proteolysis and Estrogen Receptor Target Gene Expression. [R] . Zhou, W. 2014

机译：skp1-Cul1-F-Box泛素连接酶在src刺激的雌激素受体蛋白水解和雌激素受体靶基因表达中的作用。

Expression of estrogen-induced genes and estrogen receptor β in pancreatic neuroendocrine tumors: implications for targeted therapy.

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