Efficient Synthesis of 5-Functionalised 2-Methoxypyridines and theirTransformation to Bicyclic δ-Lactams, both Accessed Using Magnesium'Ate' Complexes as Key Reagents

摘要

Simple and efficient synthesis of 5-functionalised2-methoxypyridines from 5 -bromo-2-methoxypyridine using[n-Bu_3Mg]Li performed in noncryogenic conditions is described.Application of 5-functionalised 2-methoxypyridines in the synthesisof 1-substituted 3,6,9,9a-tetrahydroquinolizin-4-ones and 3,5,8,8a-tetrahydro-1H-quinolin-2-ones via allylation of the corresponding5-functionalised N-allyl(or benzyl)pyridin-2-ones using [allyln-Bu_2Mg]Lifollowed by ring-closing metathesis is presented.