Evaluation of pancreatic function in normal pancreas as living-related donors and type 1 diabetic pancreas as recipients for pancreas transplantation using 11c-methionine positron emission tomography.

摘要

Living-donor pancreas transplantation has been developed as one of the effective therapeutic modalities for patients with type 1 diabetes. The safety to the donor is a major consideration in this procedure. The donor pancreatic endocrine function has been widely evaluated using both oral and intravenous glucose tolerance tests. Although these tests are useful for evaluation of the endocrine function of the entire organ, they cannot be used to evaluate the segmental pancreatic function. On the other hand, positron emission tomography (PET) can be used to evaluate the segmental pancreatic function, such as the functions of the remnant pancreas head after the donor operation and the pancreas body/tail as a graft for living-related pancreas transplantation.