Evidence continues to mount on the relationship of restless legs syndrome/ periodic limb movements in sleep to hypertension, cardiovascular disease, and stroke.

摘要

SINCE THE PUBLICATION OF OUR RECENT REVIEW IN SLEEP, WE HAVE BECOME AWARE OF A FEW LARGER STUDIES THAT WE EITHER DID NOT COVER IN OUR review or have come to publication recently.We are sorry that we missed the older study by Ferri et al. published in 2007, where he and coauthors show in 16 patients with restless legs syndrome (RLS) that the pulse rate elevations seen with isolated leg movements are even higher than those seen with periodic limb movements in sleep (PLMS).2 This is in contrast to the study by Guggisberg et al. quoted in our review, where 24 patients with PLMS but not RLS have pulse rate elevations with PLMS that are higher than those with isolated leg movements.6 In both studies pulse rate elevations accompanying PLMS are significant, however, and could conceivably convey additional cardiovascular risk as blood pressure elevations would be expected to follow.1