A method of treating Restless Legs Syndrome and/or Periodic Limb Movements during Sleep (RLS) comprises administration of a therapeutically effective dose of biologically active zonisamide and a dopaminergic agent selected from dopamine agonist and dopamine turnover promoting agent including dopamine uptake inhibitor over an appropriate period of time, such as a period substantially coinciding with the period of sleep of said patient. Also disclosed is a corresponding method of treatment, the use of biologically active zonisamide and a dopaminergic agent selected from dopamine agonist and dopamine turnover promoting agent including dopamine uptake inhibitor for the manufacture of a medicament for treating RLS, and a corresponding method of manufacture.
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