One-pot, four-component reaction of aryl aldehydes, aryl ketones, phosphorus trichloride, and acetonitrile catalyzed by acetyl chloride: Synthesis of beta-acetamido ketones

摘要

The one-pot, four-component reaction of aryl aldehydes, aryl ketones, phosphorus trichloride, and acetonitrile, catalyzed by acetyl chloride, affords beta-acetamido ketones in good to excellent yields. Silicaphosphine (silphos), [P(Cl)(3-n)(SiO2)(n)], can also be used effectively as a solid-supported reagent instead of phosphorus trichloride.