Efficient Synthesis of beta-Alkyl/Arylsulfanyl Carbonyl Compounds by In-TMSCl-Promoted Cleavage of Dialkyl/Diaryl Disulfides and Subsequent Michael Addition

摘要

A convenient and efficient procedure for the synthesis of beta-alkyl/arylsulfa-nyl carbonyl compounds has been developed by a simple one-pot reaction of dialkyl/diaryl sulfides with alpha,beta-unsaturated aldehydes,ketones,carboxylic esters,and nitriles in presence of indium and trimethylsilyl chloride under sonication.