Alternative Synthesis of 1,2,3,4-Tetramethoxy-5-methyIbenzene:A Key Intermediate for Preparing Coenzyme Q Homologs and Analogs

摘要

Preparation of 1,2,3,4-tetramethoxy-5-methylbenzene (1) through a new process from pyrogallol is described.In the preparation,a modified mild brominating agent was employed,and a simple introduction of methyl group into aromatic ring through chloromethylation of the corresponding substrate (4),followed by reductive dehalogenation,was achieved successfully with good yields.