ESR and electrochemical study of 1,2-disubstituted 5-nitroindazolin-3-ones and 2-substituted 3-alkoxy-5-nitro-2H-indazoles: Reactivity and free radical production capacity in the presence of biological systems

摘要

Two families of 5-nitroindazole derivatives were electrochemically studied in an aprotic solvent using cyclic voltammetry (CV) technique. The produced nitro-anion radical species were characterized using electron spin resonance spectroscopy (ESR). Also, we examined the interaction between the radical species generated from nitroindazole derivatives and glutathione (GSH). Moreover, the capacity of intra-parasite and intramammals-free radical production, through ESR spectroscopy, was performed. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.