首页> 外文期刊>Sports medicine >Neutrophil Extracellular Traps: A Walk on the Wild Side of Exercise Immunology
【24h】

Neutrophil Extracellular Traps: A Walk on the Wild Side of Exercise Immunology

机译:中性粒细胞胞外诱捕:运动免疫学的狂野一面

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料

摘要

Intense exercise evokes a rapid and transient increase in circulating cell-free DNA (cf-DNA), a phenomenon that is commonly observed in a variety of acute and chronic inflammatory conditions. While the potential value of cf-DNA for the prediction of disease outcome and therapeutic response is well documented, the release mechanisms and biological relevance of cf-DNA have long remained enigmatic. The discovery of neutrophil extracellular traps (NETs) provided a novel mechanistic explanation for increased cf-DNA levels. Now there is increasing evidence that NETs may contribute to cf-DNA in diverse infectious, non-infectious and autoinflammatory conditions, as well as in response to acute exercise. NETs have now been firmly established as a fundamental immune mechanism used by neutrophils to respond to infection and tissue injury. On the other side, aberrant formation of NETs appears to be a driving force in the pathogenesis of autoimmunity and cardiovascular disease. Thus, the emergence of NETs in the 'exercising vasculature' raises important questions considering beneficial effects, as well as occasional adverse effects, of exercise on immune homeostasis. This review gives an overview of the current state of research into the mechanisms of how NETs are released, contribute to host defence and participate in inflammatory disorders. We discuss the impact of exercise-induced NETs, considering a potentially beneficial role in the prevention of lifestyle-related diseases, as well as putative detrimental effects that may arise in elite sports. Finally, we propose that exercise-induced cf-DNA responses could be exploited for diagnostic/prognostic purposes to identify individuals who are at increased risk of cardiovascular events or autoimmunity.
机译:激烈的锻炼会引起循环性无细胞DNA(cf-DNA)的快速和短暂增加,这种现象在各种急性和慢性炎症性疾病中都普遍观察到。尽管cf-DNA在预测疾病结局和治疗反应方面的潜在价值已得到充分证明,但cf-DNA的释放机制和生物学相关性长期以来一直是谜。中性粒细胞胞外陷阱(NETs)的发现为增加cf-DNA水平提供了一种新颖的机理解释。现在,越来越多的证据表明,NETs可能在多种传染性,非传染性和自身炎性疾病以及对急性运动的反应中对cf-DNA起作用。 NETs已被牢固地确立为中性粒细胞用于应对感染和组织损伤的基本免疫机制。另一方面,NETs的异常形成似乎是自身免疫和心血管疾病发病机理的驱动力。因此,NETs在“运动性脉管系统”中的出现提出了重要的问题,考虑到运动对免疫稳态的有益作用以及偶然的不利影响。这篇综述概述了有关NETs释放机制,促进宿主防御和参与炎症性疾病的机制的研究现状。考虑到预防生活方式相关疾病的潜在有益作用以及精英运动中可能产生的不利影响,我们讨论了运动引起的NET的影响。最后,我们建议可以将运动诱发的cf-DNA反应用于诊断/预后目的,以识别心血管事件或自身免疫风险增加的个体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号