首页> 外文期刊>South African medical journal: Suid-Afrikaanse tydskrif vir geneeskunde >Symptomatic hyperlactataemia in adults on antiretroviral therapy: a single-centre experience.
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Symptomatic hyperlactataemia in adults on antiretroviral therapy: a single-centre experience.

机译:成人接受抗逆转录病毒治疗的症状性高乳酸血症:单中心经验。

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摘要

OBJECTIVE: There are limited data on symptomatic hyperlactataemia caused by antiretroviral therapy (ART) in resource-limited settings. We assessed individuals who developed symptomatic hyperlactataemia on ART in an outpatient clinic in South Africa. DESIGN: A retrospective record review was performed on patients attending the clinic from January 2004 to December 2005. RESULTS: Thirty-five patients, all on stavudine-containing regimens, developed symptomatic hyperlactataemia. The incidence in this population was 20.5 cases per 1 000 person-years of ART with an associated mortality of 21%. The major risk factor was being female (risk ratio (RR) 3.27). Significant clinical symptoms preceding symptomatic hyperlactataemia include nonspecific gastrointestinal symptoms, weight loss, and development of symptomatic neuropathy. CONCLUSIONS: The incidence of symptomatic hyperlactataemia in our population was high. Simple clinical measures, such as neuropathy symptoms and monitoring of weight, may alert the clinician to impending symptomatic hyperlactataemia. Early diagnosis expedites safe outpatient care and switching of ART regimens without interruption, in many cases.
机译:目的:在资源有限的情况下,由抗逆转录病毒疗法(ART)引起的症状性高乳酸血症的数据有限。我们评估了在南非一家门诊诊所因ART出现症状性高乳酸血症的患者。设计:对2004年1月至2005年12月期间就诊的患者进行回顾性记录审查。结果:35例患者均采用司他夫定治疗,出现了症状性高乳酸血症。该人群的发病率为每1000人年ART 20.5例,相关死亡率为21%。主要危险因素是女性(风险比(RR)3.27)。有症状的高乳酸血症之前的重要临床症状包括非特异性胃肠道症状,体重减轻和有症状的神经病变。结论:我国人群有症状的高乳酸血症发生率很高。简单的临床措施,例如神经病症状和体重监测,可能会提醒临床医生即将出现症状性高乳酸血症。在许多情况下,早期诊断可加快安全的门诊治疗速度,并在不中断治疗的情况下切换ART方案。

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