Skin Care Formulation Incorporating Natural Moisturising Factor and its Efficacy on Asian Skin

摘要

The skin has the property to retain water in order to maintain its proper barrier function.In situations of environmental stress,age or intrinsic physiological disturbances,this function is maintained only in part.The water storage capacity of the skin decreases with an increased water loss by evaporation (transepidermal water loss,TEWL),resulting in a dry,deep-wrinkled or even squamous skin.The reconstitution of skin moisture is thus one of the main targets for skin care formulations.Principally skin moisture can be improved either by hydrophilic substances binding water on the skin surface-humectants (1),or by enriching the natural moisturizing factor (NMF) of the skin (2-5).Typical examples of humectants are glycerol,sorbitol and propylene glycol.On the other hand,NMF is a complex mixture of low molecular weight,water-soluble compounds such as amino-acids (mainly serine,alanine and citroline),pyrrolidone carboxylic acid (PCA),lactic acid,or their respective salts,and urea,which are naturally present in the stratum corneum (6).This paper highlighted a comparative moisturizing efficacy of skin care formulation based on an 0/W emulsion incorporating various NMF i.e.sodium lactates,sodium PCA and lauryl PCA at various concentrations @1%,3% and 5% active against a placebo containing a humectant,glycerin @3%.The study was conducted at the Efficacy Laboratory,AOTO (Advanced Oleo-chemical Technology Division),MPOB (Malaysian Palm Oil Board),Malaysia on Asian skin namely Malaysian.