P-cadherin-mediated Rho GTPase regulation during collective cell migration

摘要

This commentary addresses the role of P-cadherin in collective cell migration (CCM), a cooperative and coordinated migration mode, used by cells during normal and pathological migration processes. We discuss how cadherin-mediated cell-cell junctions (CCJs) play a critical role in CCM through their ability to regulate Rho GTPase-dependent pathways and how this leads to the generation and orientation of mechanical forces. We will also highlight the key function of Podherin (a poor prognostic marker in several tumors) in promoting collective cell movement in epithelial and mesenchymal cells.