Chemical Approaches to Controlling Intracellular Protein Degradation

摘要

A major goal of post-genomic research is to understand and control the function of specific proteins within the proteome.The fields of genetics,genomics,and chemical genetics attempt to study this problem from two fundamentally different approaches.The traditional genetic approach or genomic analysis involves the observation of a particular phenotype,identification of the molecule(s)responsible for that phenotype,and subsequent analysis and manipulation of the corresponding genetic sequence.In contrast,chemical genetics attempts to use small molecules as probes to perturb signaling pathways at the molecular level in the hopes of identifying novel proteins responsible for a particular phenotype.These two distinct approaches(among others)have yielded huge advances in the understanding of protein function.Despite their differences,these fields share the same strategy of inactivation of a protein to study its function.