Large-Scale Parallel Surface Functionalization of Goblet-type Whispering Gallery Mode Microcavity Arrays for Biosensing Applications

摘要

Photonic microstructures based on whispering gallery modes(WGM) are of great interest for biomolecular detection with high sensitivity. Mostly, they provide highly narrow spectral resonances, allowing for biosensing with high resolution and low detection limits. Smallest spectral shifts resulting from binding events to the cavity surfaces may be discriminated. It has been demonstrated that binding of proteins with picomolar concentrations, single viruses and nanoparticles can be detected. This is opening promising perspectives utilizing WGM cavities as powerful sensing tools, e.g. for medical diagnostics and environmental monitoring. Prominent cavity structures include microtoroids, microgoblets, microspheres, microrings, and capillaries. Especially highly integrated on-chip approaches offer the realization of compact sensing platforms with high transducer density.